Reporters learned from the Institute of Zoology of the Chinese Academy of Sciences on the 16th that researchers from the Institute, Xuanwu Hospital of Capital Medical University and other units have successfully constructed a new type of engineered human anti-aging mesenchymal progenitor cell (SRC), which can resist aging, cope with various pressures and avoid canceration. They also validated the effect of this cell in delaying multi organ aging in monkeys, providing a new cell therapy method for humans to fight aging. The relevant research results were published online in Cell. As we age, the number of stem cells in our body gradually decreases, leading to a decline in our body's ability to repair and maintain homeostasis, which is key to aging and related diseases. But is the decrease in stem cells a cause or a result of aging? Can supplementing stem cells from outside effectively delay aging? These issues have always troubled scientists. Meanwhile, it is difficult for foreign stem cells to settle in the aging body, and their stay time is short, which may also pose a risk of cancer, all of which hinder the use of stem cells for anti-aging. In this study, researchers have gone through more than ten years of research and created an "anti-aging version" of mesenchymal progenitor cells through gene editing technology. To verify the effect, researchers selected elderly crab eating monkeys equivalent to humans aged 60-70 for the experiment. During the 44 week experiment, they administered multiple intravenous injections of this anti-aging cell to the monkeys. The experimental results proved that injecting this anti-aging cell showed safety and immune tolerance in non-human primate models, and there were no adverse reactions during the entire process. Detailed examination also ruled out tissue damage and tumor risks. More importantly, these anti-aging cells significantly delay the aging process of multiple organs in monkeys, helping their bodies restore homeostasis, improve cognitive abilities, alleviate various tissue degeneration and lesions, reduce the accumulation of aging cells in the body, and make the cells themselves healthier and more stable. Through in-depth analysis, it was found that over half of the aging related gene activity patterns in tissues have become younger; At the single-cell level, the expression of aging genes in key cells has been successfully reversed; The analysis of the "aging clock" established using artificial intelligence shows that the biological age of immature nerve cells is 6-7 years younger, and the biological age of egg cells is 5 years younger. Research has found that the reason why these anti-aging cells are so powerful is that they can release small vesicles called "exosomes". These extracellular vesicles act as messengers that transmit the 'youthful signal', promoting the rejuvenation of other cells, inhibiting chronic inflammation, and helping to maintain the stability of cellular genetic material. It is reported that this study has broken through the limitations of traditional "single disease treatment" and demonstrated for the first time that engineered cells can systematically delay multi organ aging, laying the foundation for the development of universal anti-aging therapies and opening up new paths for human active intervention in aging and extending healthy lifespan. It is expected to promote the transformation of anti-aging medicine from "passive response" to "active programming". (New Society)