A research paper on aging published online on the evening of June 30th Beijing time in the professional academic journal "Nature Aging" under Springer Nature stated that inflammatory aging is a chronic low-grade inflammation related to aging, but not all populations' aging is related to chronic inflammation. A study conducted by researchers shows that people with less industrialized lifestyles may not experience inflammatory aging. The research results are based on data from two industrialized populations in Italy and Singapore, as well as two local residents and non industrialized populations in the Bolivian Amazon and the Malaysian Peninsula. The paper introduces that short-term inflammation is crucial for curing infections, but long-term exposure to inflammation (inflammatory aging) is known to increase the risk of biological aging and age-related diseases. However, it was previously uncertain whether the impact of inflammatory aging on all populations was consistent. In this study, co corresponding authors Maximilien Franck from Sherbrooke University in Canada and Alan A. Cohen from Columbia University in the United States, along with collaborators, analyzed datasets of 19 cytokines (small proteins involved in inflammation) from two industrialized cohort studies in Italy and Singapore, as well as two non industrialized cohorts in the Bolivian Amazon and the Malaysian Peninsula. In the industrial cohort, they observed a consistent feature of inflammation increasing with age, which is associated with chronic age-related diseases such as stroke, cardiovascular disease, and cancer. However, in both non industrial cohorts, they did not find an increase in inflammation with age. Meanwhile, chronic age-related diseases are also rare in these cohorts and are not associated with inflammatory aging. The authors of the paper point out that the results of this study indicate the importance of considering cultural, environmental, and lifestyle factors when studying the aging process, challenging existing paradigms around inflammatory aging. They believe that further research or exploration of how specific environmental conditions regulate inflammatory aging and its impact on health outcomes may lead to the development of more targeted strategies to prevent age-related diseases in different populations worldwide. (New Society)