In May of this year, the national Class 1.1 innovative Chinese medicine drug Yiqi Tongqiao Wan, which took 20 years to develop, was launched nationwide through Phase III clinical trials. It will be used for the clinical treatment of allergic rhinitis and a real-world study will be conducted to collect 10000 sample data. Innovative traditional Chinese medicine refers to new prescription preparations of traditional Chinese medicine that are not included in national drug standards, drug registration standards, and the "Catalogue of Ancient Classic Prescriptions" published by the national traditional Chinese medicine regulatory department, have clinical value, and have not been listed overseas. They mostly refer to compound preparations of traditional Chinese medicine composed of multiple herbal pieces, extracts, and other ingredients under the guidance of traditional Chinese medicine theory. How to leverage the unique advantages of traditional Chinese medicine and turn its effective formulas into innovative medicines? Activate famous prescriptions, innovate drugs with precise and effective results. "One piece of data activates two famous prescriptions. ”In the laboratory, the fragrance of medicine permeated the air. Hou Jincai, the director of the Traditional Chinese Medicine Research Institute of Yangtze River Pharmaceutical Group, held the test results in his hands and was filled with emotion. Yiqi Tongqiao Pill is a combination of effective ingredients from the modern empirical formula "Allergy Decoction", carefully developed using modern pharmaceutical technology. Modern medical research has shown that several medicinal herbs, such as Huangqi and Fangfeng, in classic formulas can synergistically act on multiple stages of disease and have a significant bidirectional regulatory effect on immune function; In modern society, there is an increase in allergens, and the integration of classic formulas into the current formula 'Allergy Decoction' can more accurately target the allergic process and enhance the anti allergic effect. ”Hou Jincai said that refining the essence of Chinese medicine wisdom with modern "precision medicine" and improving the classics according to modern "changes in disease spectrum" is the first step in developing innovative Chinese medicine. The efficacy needs to be validated through modern data research. Hou Jincai introduced that according to the results of the Phase III controlled trial of the new drug, the treatment group showed significant efficacy, with a "disappearance rate of runny nose symptoms" of 52.65% and a "disappearance rate of tearing symptoms" of 80.97%. 30% of patients did not experience a recurrence of rhinitis within one year after two weeks of medication, indicating the potential long-term effectiveness of the new drug in treating rhinitis. From 'experience support' to 'data support', it has always been a research and development difficulty for Mingfang transformation. ”Hou Jin just said. Yiqi Tongqiao Pill is used to treat allergic rhinitis. It is reported that the research and development team of this new drug plans to build a specialized disease database and conduct large-scale real-world research. The study is expected to cover over 100 research centers and include up to 10000 samples, aiming to provide more comprehensive and reliable scientific evidence for the clinical value evaluation of new drugs. Make good traditional Chinese medicine and improve its quality through intelligent technology. Classic formulas are quantified based on the weight of medicinal materials, and the effective ingredients of medicinal materials may vary in content depending on the region, climate, and planting techniques. Ensuring the quality, safety, and stability of raw materials tests the supply chain management capabilities of modern pharmaceutical companies. The 14 medicinal herbs of Yiqi Tongqiao Pill are all sourced from high-quality production areas and standardized planting bases under Yangtze River Pharmaceutical Group. Digital technology runs through planting, harvesting, processing, and sales, achieving full chain quality traceability. At the end of the research, it costs three yuan per serving, one and a half cups of water, three slices of ginger, and fried. ”This is the processing method of "Yupingfeng Powder" in ancient books - most of the classic famous prescriptions are decoction, and 1.1 innovative traditional Chinese medicines are composed of "extracts". This change tests the ability and wisdom of scientific researchers to "take its essence". The Yangtze River Longfengtang Traditional Chinese Medicine Industrial Park, located in Taizhou, Jiangsu, has an automation and intelligence level of over 80%. The main ingredient of Yiqi Tongqiao Pill, Huangqi, undergoes four main processes in the extraction workshop, continuously transforming from medicinal herbs into "concentrated extraction solution". When workshop director Wang Ming first entered the industry 15 years ago, he learned all the skills of traditional Chinese medicine preparation from the older generation of decoction masters. For the next 10 years, he stayed by the high-temperature boiler every day, personally boiling medicine and manually operating various valves. At that time, it was all based on experience, and the quality fluctuated greatly, "Wang Ming said. In 2020, the intelligent extraction workshop was completed and put into operation. Wang Ming switched careers to become an engineer, studying the theory of traditional Chinese medicine processing and modern chemical knowledge, optimizing various parameters in intelligent control systems. Nowadays, hundreds of control valves are controlled by intelligent systems. The extracted liquid produced in the workshop has uniform quality and more stable efficacy. Make good use of traditional Chinese medicine and continuously expand its application scenarios. The "Opinions on Improving the Quality of Traditional Chinese Medicine and Promoting the High quality Development of the Traditional Chinese Medicine Industry" issued by the General Office of the State Council proposes to accelerate the transformation and upgrading of the traditional Chinese medicine industry. Promote the development of industrial chain extension through the integration of traditional Chinese medicine and enrich the high-quality supply of health food, food and drug substances, and other products. Utilizing AI technology to explore the efficacy of natto and red yeast, and launching natto red yeast capsules; Relying on the traditional Chinese medicine Pangdai, we have carefully created a diversified product line including Lanqin throat candy, gummies, solid drinks, and tea bags; By utilizing the traditional Chinese medicine Huangqi, we have innovatively launched a "fashionable single product" Huangqi coffee... Gu Chengming, the head of the marketing department of Yangtze River Pharmaceutical Group, introduced: "Traditional Chinese medicine culture emphasizes the concept of 'medicine and food sharing the same origin'. We have over 30 health products and snacks containing traditional Chinese medicine ingredients on sale." "Cultivating the application scenarios of traditional Chinese medicine culture through public welfare actions is a new trend in the marketing of the traditional Chinese medicine industry. ”Gu Chengming introduced that by promoting traditional Chinese medicine health services, Yangtze River Pharmaceutical Group has conducted multiple free consultations with academicians and traditional Chinese medicine experts nationwide; Promote the health culture of traditional Chinese medicine and organize employees and citizens to practice the Eight Section Brocade together; To enhance the public's scientific understanding of traditional Chinese medicine, we will collaborate with the media to launch a series of health programs. Explore the unique advantages of traditional Chinese medicine in the field of 'preventing diseases before they occur'. ”Xu Haoyu, Secretary of the Party Committee, Chairman, and President of Yangtze River Pharmaceutical Group, stated that the company is deeply cultivating and exploring the big health industry, striving to bring more products and services that meet consumers' health needs into millions of households. (New Society)