On September 23rd, it was learned from Hainan University that the team led by Associate Professor Guo Dongbo from the School of Biomedical Engineering has made new progress in tumor chemotherapy. The team has developed a temperature sensitive hydrogel that can effectively inhibit tumor, providing a new idea for the treatment of malignant tumors. The relevant results were recently published in Advanced Functional Materials. In the current field of cancer treatment, traditional chemotherapy has problems such as significant side effects, high recurrence rate, and easy metastasis, and the actual treatment effect is not satisfactory. In this context, some emerging treatment methods are gradually emerging, among which the "hunger therapy" that blocks tumor nutrition supply has shown excellent anti-tumor potential. However, due to the strong mutagenicity and adaptability of tumors, hydrogel mediated single mode hunger therapy is often difficult to achieve lasting effects, which becomes a bottleneck to be broken through in this field. To this end, Guo Dongbo's team innovatively developed a dual-mode treatment strategy triggered by temperature sensitivity. By constructing injectable interpenetrating polymer network hydrogel, the team organically integrated two treatment mechanisms: on the one hand, it effectively blocked the tumor nutrition supply by utilizing the internal stress generated by extravascular gel contraction to achieve accurate "hunger treatment"; On the other hand, the hydrogel in situ phase change is triggered by human body temperature, which releases local high temperature and directly kills tumor cells. The research data show that the interpenetrating polymer network hydrogel can significantly reduce the vascular density in the tumor area, effectively induce hypoxia and apoptosis of tumor cells, and finally achieve efficient tumor suppression. This achievement not only provides a new approach for the treatment of malignant tumors without chemotherapy drugs, but also has the potential to develop safer and more effective treatment plans for clinical cancer treatment, promoting the development of tumor treatment technology towards precision and low toxicity. (New Society)