Look! Our cutting-edge technology requires most ophthalmic surgeries to close the incision or fix the tissue with sutures, but sutures can bring potential risks such as corneal astigmatism, neovascularization, infection, rejection, and postoperative suture removal. In this context, ophthalmic adhesive bioactive materials have gradually become a research hotspot in the fields of ophthalmology and biomaterials. Recently, Professor Yuan Jin, Dean of Beijing Tongren Hospital affiliated with Capital Medical University, and his team published the latest research results in the journal "Bioactive Materials", systematically elaborating on the latest progress of ophthalmic adhesive bioactive materials. It is understood that ophthalmic adhesive bioactive materials not only need to achieve reliable adhesion in dynamic environments with high humidity, frequent blinking, and intraocular pressure fluctuations, but also need to have good optical properties, biocompatibility, and controllable degradation characteristics; At the same time, it should also serve as a delivery carrier for drugs or cells, providing minimally invasive and renewable comprehensive treatment options for eye diseases. The lengthy review published by Yuan Jin's team this time summarizes the latest progress of ophthalmic adhesive bioactive materials from the aspects of adhesion mechanism, material system design, ocular surface and fundus applications, coupling of intelligence and regenerative medicine, and clinical translation prospects, providing systematic guidance for basic research and clinical applications in this field. In response to the clinical needs of ocular surface and corneal diseases, the article reveals a shift in material construction strategies from simple physical closure to multifunctional biomimetic construction. By introducing biomimetic adhesion, constructing interpenetrating or dual network structures, and integrating bioactive ingredients, the latest ocular surface adhesive developed by the team can achieve seamless corneal transplantation, filling and regeneration of large-scale matrix defects, and even immediate closure of complex wounds under wet and bleeding conditions. It shows certain potential in expanding the application scenarios of ocular surface repair and improving the quality of prognosis. In response to the clinical needs of retinal diseases, research has repositioned retinal adhesives as a multidimensional intervention platform that integrates structural support, local microenvironment regulation, and long-term treatment functions. On this basis, researchers further pointed out that adhesive bioactive materials can not only maintain retinal adhesion and close retinal holes after vitrectomy, but also achieve precise matching of adhesion strength, in vivo residence time, and degradation kinetics by regulating polymer substitution degree and concentration, constructing a three-dimensional microenvironment that combines adhesion and cell scaffold function. In addition, the review further expands the research perspective to the synergistic application of bioactive molecules such as growth factors, anti VEGF drugs, and extracellular vesicles with adhesive materials, achieving comprehensive effects such as anti-inflammatory, anti neovascularization, and neuroprotection in a multi-target manner. This transforms the adhesive bioactive materials in the fundus from simple mechanical patches to programmable local treatment platforms, providing a key implementation tool for the treatment of fundus diseases. Industry experts say that in the future, new materials will develop towards a more intelligent and compatible direction with human tissues, including: through technologies such as 3D printing, materials can better simulate the mechanical and optical properties of natural tissues; By endowing materials with the ability to respond to stimuli such as temperature and enzymes, on-demand drug release can be achieved; Combined with stem cell therapy, it can actively regulate the microenvironment and promote tissue regeneration. (New Society)