Domestic automatic analyzer for cerebrospinal fluid cell morphology development successfully completed-瞭望新时代网-瞭望时代，放眼世界

Domestic automatic analyzer for cerebrospinal fluid cell morphology development successfully completed

2026-07-13

Cerebrospinal fluid (CSF) cytology testing is a core basis for clinical diagnosis of neurological diseases. China is poised to achieve autonomous control over high-end diagnostic equipment in this field. Recently, reporters learned from the Ningxia Hui Autonomous Region Department of Science and Technology that the “CSF Cell Morphology Automatic Analyzer,” developed by Professor Wang Zhenhai’s team from the Affiliated Hospital of Ningxia Medical University in collaboration with Hangzhou Zhiwei Microbiology Technology Co., Ltd., may break the long-term monopoly of foreign high-end pathological diagnostic equipment. Cells in cerebrospinal fluid are characterized by low quantity and diverse morphology, with significant heterogeneity in morphological changes after disease onset. Conventional cell analyzers used for blood, bone marrow, and urine testing cannot meet the requirements of CSF detection. Currently, most domestic medical institutions still rely on manual visual interpretation using optical microscopes, and there is a shortage of specialized technical personnel for CSF testing. Only a few tertiary hospitals possess complete testing capabilities, which greatly restricts early screening, diagnosis, and treatment plan formulation for neurological diseases. Targeting clinical pain points, Wang Zhenhai’s team has focused on frontline research for over a decade. They initiated basic research on the CSF cell recognition and analysis system in 2012; in 2018, leveraging the Ningxia Key R&D Special Project, they built a standardized CSF cell feature database and developed an intelligent recognition system; in 2020, with approval from the Ningxia Hui Autonomous Region Department of Science and Technology, the Ningxia Engineering Technology Research Center for Neurological Disease Diagnosis and Treatment was officially established, further refining the recognition system based on artificial intelligence technology. In 2022, the project was selected as a major scientific and technological achievement transformation special project in the autonomous region, and the first-generation engineering prototype was launched, marking that its core technology had entered the critical stage of industrialization transformation. Since then, the R&D team has continued to iterate, and on June 6, 2025, led by the Affiliated Hospital of Ningxia Medical University, multi-center clinical testing was launched in conjunction with tertiary hospitals in Hebei, Chongqing, Guangdong, and other regions, accelerating the implementation of the technology. Wang Zhenhai introduced that the analyzer covers the entire process of high-definition image scanning, AI-powered intelligent cell classification and recognition, and standardized report generation. Compared with traditional manual microscopic examination, the equipment has lower comprehensive usage costs, significantly improved testing efficiency, can achieve full-field coverage of sample fields of view, higher cell recognition accuracy, and simple operation, making it adaptable to clinical testing needs of medical institutions at all levels, effectively solving the industry’s testing shortcomings. In the next step, the R&D team will integrate cutting-edge technologies such as CSF cell laser segmentation and spatial proteomics to develop a new analysis system integrating cell detection and functional analysis, providing technical support for research on the pathogenesis of neurological diseases and clinical precision diagnosis and treatment.

Edit：WENWEN Responsible editor：LINXUAN

Source：Science and Technology Daily

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